2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester

Base Information

Chemical Name:2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester
CAS No.:1455091-47-0
Molecular Formula:C₃₀H₃₅N₃O₅
Molecular Weight:517.625
Hs Code.:

Synonyms:2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester

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Chemical Property of 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester

Chemical Property:

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Technology Process of 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester

There total 3 articles about 2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455091-23-2
1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

: 1455091-44-7
2-aminomethyl-2-propylpentanoic acid tert-butyl ester

: 1455091-47-0
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester

Guidance literature:: In methanol; at 120 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1116-98-9
cyanoacetic acid tert-butyl ester

: 1455091-47-0
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

2: hydrogen / methanol / 20 °C

3: methanol / 2 h / 120 °C / Microwave irradiation

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1455091-34-5
2-cyano-2-propylpentanoic acid tert-butyl ester

: 1455091-47-0
2-{[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}-2-propyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / methanol / 20 °C

2: methanol / 2 h / 120 °C / Microwave irradiation

With hydrogen; In methanol;