N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

Base Information

• Chemical Name: N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine
• CAS No.: 92893-50-0
• Molecular Formula: C₁₈H₂₂Cl₃NO₆
• Molecular Weight: 454.735
• Mol file: 92893-50-0.mol

Synonyms:N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

Chemical Property of N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

There total 4 articles about N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine t-butyl ester (92893-49-7) → N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine (92893-50-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 8h; Ambient temperature;

Reference yield:

N-<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanine tert-butylester (80828-38-2) → N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine (92893-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / pyridine / tetrahydrofuran / 3 h / Heating

2: 76 percent / 4N HCl / dioxane / 8 h / Ambient temperature

With pyridine; hydrogenchloride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

N-[(1S)-1-ethoxycarbonyl-3-phenylpropyl]-D-alanine t-butyl ester (84385-19-3) → N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine (92893-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; triethylamine / tetrahydrofuran; ethyl acetate; acetonitrile

2: 1,4-dioxane; hydrogenchloride

With potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; ethyl acetate; acetonitrile;

upstream raw materials:

N-<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine t-butyl ester

N-<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanine tert-butylester

N-[(1S)-1-ethoxycarbonyl-3-phenylpropyl]-D-alanine t-butyl ester

Downstream raw materials:

N-[N'-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-4-[N²-(3-sulfamyl-4-chlorobenzoyl)hydrazino]-L-proline

N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline S,S-dioxide

N-[N'-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-(4S)-4-{[(6-chloro-1,2,4-benzothiadiazin-7-yl)sulfonyl]amino}-L-proline S,S-dioxide

1'-[N'-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-5'-carboxy-7-(aminosulfonyl)-6-chlorospiro(2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine) S,S-dioxide