(2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Base Information

• Chemical Name: (2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal
• CAS No.: 476015-19-7
• Molecular Formula: C₂₅H₃₉BrN₂O₅S₂
• Molecular Weight: 591.631
• Mol file: 476015-19-7.mol

Synonyms:(2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Chemical Property of (2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

There total 7 articles about (2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,8-dibromooctane (4549-32-0) + (2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal (140647-02-5) → (2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal (476015-19-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2008.04.006

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → (2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal (476015-19-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / K₂CO₃ / acetone / Heating

2: 90 percent / HNO₃; SnCl₄ / CH₂Cl₂ / -25 °C

3: 88 percent / 2N aq. LiOH / tetrahydrofuran; methanol / 20 °C

4: SOCl₂; DMF / benzene

5: 532 mg / Et₃N / tetrahydrofuran

With lithium hydroxide; thionyl chloride; nitric acid; tin(IV) chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetone; benzene;

DOI:10.1021/jm020124h

Reference yield:

1,8-dibromooctane (4549-32-0) → (2S)-N-[4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal (476015-19-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / K₂CO₃ / acetone / Heating

2: 90 percent / HNO₃; SnCl₄ / CH₂Cl₂ / -25 °C

3: 88 percent / 2N aq. LiOH / tetrahydrofuran; methanol / 20 °C

4: SOCl₂; DMF / benzene

5: 532 mg / Et₃N / tetrahydrofuran

With lithium hydroxide; thionyl chloride; nitric acid; tin(IV) chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetone; benzene;

DOI:10.1021/jm020124h

upstream raw materials:

(2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole

4-hydroxy-3-methoxybenzoic acid methyl ester

1,8-dibromooctane

methyl 4-(3-bromooctyloxy)-3-methoxybenzoate

Downstream raw materials:

(2S)-N-{4-[methyl-(2S)-N-(5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxylate-4-yloxy]octyloxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

(2S)-N-{4-[3-(7-methoxy-(11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c]-[1,4]benzodiazepine-5,11-dione-8-yloxy)octyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

C₂₅H₃₉N₅O₅S₂

(2S)-N-{4-[3-(7-methoxy-(11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c]-[1,4]benzodiazepine-5,11-dione-8-yloxy)octyloxy]-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal