Technology Process of (2R,4S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid [4-(2,2,2-trifluoro-ethoxy)-phenyl]-amide
There total 5 articles about (2R,4S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid [4-(2,2,2-trifluoro-ethoxy)-phenyl]-amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 0 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / Inert atmosphere
2.2: 0.17 h / 10 °C
3.1: sodium carbonate / tetrahydrofuran / 0.25 h
3.2: 2 h / 20 °C
4.1: 1H-imidazole / dichloromethane / 2 h / 20 °C / Cooling with ice
5.1: lithium borohydride / tetrahydrofuran / 2 h / 0 °C
5.2: 0 °C
With
1H-imidazole; lithium borohydride; hydrogen; sodium hydrogencarbonate; sodium carbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / 0 °C
1.2: 2 h / 5 - 20 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 0 °C / Inert atmosphere
3.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / Inert atmosphere
3.2: 0.17 h / 10 °C
4.1: sodium carbonate / tetrahydrofuran / 0.25 h
4.2: 2 h / 20 °C
5.1: 1H-imidazole / dichloromethane / 2 h / 20 °C / Cooling with ice
6.1: lithium borohydride / tetrahydrofuran / 2 h / 0 °C
6.2: 0 °C
With
1H-imidazole; lithium borohydride; hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / Inert atmosphere
1.2: 0.17 h / 10 °C
2.1: sodium carbonate / tetrahydrofuran / 0.25 h
2.2: 2 h / 20 °C
3.1: 1H-imidazole / dichloromethane / 2 h / 20 °C / Cooling with ice
4.1: lithium borohydride / tetrahydrofuran / 2 h / 0 °C
4.2: 0 °C
With
1H-imidazole; lithium borohydride; sodium hydrogencarbonate; sodium carbonate;
In
tetrahydrofuran; dichloromethane;
