(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}urea

Base Information

• Chemical Name: (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}urea
• CAS No.: 1610545-72-6
• Molecular Formula: C₂₀H₁₅F₆N₅O₂S
• Molecular Weight: 503.428

Synonyms:(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}urea

Chemical Property of (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}urea

Chemical Property:

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Technology Process of (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}urea

There total 8 articles about (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ6-sulfanylidene}cyanamide (1610545-63-5) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ6-sulfanylidene}urea (1610545-72-6)

Guidance literature:

With trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

tert-butyl {3-[(methylsulfanyl)methyl]-5-(trifluoromethyl)phenyl}carbamate (1427315-82-9) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ6-sulfanylidene}urea (1610545-72-6)

Guidance literature:

Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; butan-1-ol / 72 h / 140 °C

3: [bis(acetoxy)iodo]benzene / dichloromethane / 1.17 h / 0 - 20 °C

4: potassium permanganate / acetone / 0.5 h / 40 °C

5: trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

With hydrogenchloride; potassium permanganate; [bis(acetoxy)iodo]benzene; trifluoroacetic acid; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane; acetone; butan-1-ol;

Reference yield:

4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfanyl)methyl]-5-(trifluoromethyl)phenyl}pyrimidin-2-amine (1604819-36-4) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)oxido-λ6-sulfanylidene}urea (1610545-72-6)

Guidance literature:

Multi-step reaction with 3 steps

1: [bis(acetoxy)iodo]benzene / dichloromethane / 1.17 h / 0 - 20 °C

2: potassium permanganate / acetone / 0.5 h / 40 °C

3: trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

With potassium permanganate; [bis(acetoxy)iodo]benzene; trifluoroacetic anhydride; In dichloromethane; acetone;

upstream raw materials:

tert-butyl {3-[(methylsulfanyl)methyl]-5-(trifluoromethyl)phenyl}carbamate

3-[(methylsulfanyl)methyl]-5-(trifluoromethyl)aniline

4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfanyl)methyl]-5-(trifluoromethyl)phenyl}pyrimidin-2-amine

(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](methyl)-λ⁴-sulfanylidene}cyanamide

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