(3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

Base Information

Chemical Name:(3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone
CAS No.:916452-44-3
Molecular Formula:C₂₈H₃₉N₃O₆
Molecular Weight:513.634
Hs Code.:

Synonyms:(3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

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Chemical Property of (3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

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Technology Process of (3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

There total 1 articles about (3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-amino-4-methyl-pentanoic acid 1-{3-[1-(2-carboxy-ethylcarbamoyl)-2-(4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-but-3-enyl ester; hydrochloride

: 916452-44-3
(3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: With diphenylphosphoranyl azide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 ℃; for 10h;
DOI:10.1016/j.bmc.2006.07.019

Reference yield: 54.0%

: 916452-44-3
(3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

: 90609-50-0
(4-Iod-benzyl)-(methoxymethyl)-ether

: 916452-52-3
(3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-{(1R)-3-[4-(methoxymethoxymethyl)phenyl]-1-methylallyl}-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: With tetrabutyl-ammonium chloride; sodium hydrogencarbonate; triphenylphosphine; palladium diacetate; In water; N,N-dimethyl-formamide; at 80 ℃; for 40h;
DOI:10.1016/j.bmc.2006.07.019

Reference yield:

: 916452-44-3
(3S,10R,16S)-3-isobutyl-10-(4-methoxybenzyl)-16-[(1R)-1-methylallyl]-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

: 916452-54-5
(3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / PPh₃; tetra-n-butylammonium chloride; NaHCO₃ / Pd(OAc)2 / dimethylformamide; H₂O / 40 h / 80 °C

2: 72 percent / aq. HCl / methanol / 3 h / 0 °C

With hydrogenchloride; tetrabutyl-ammonium chloride; sodium hydrogencarbonate; triphenylphosphine; palladium diacetate; In methanol; water; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/j.bmc.2006.07.019