{4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone

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Chemical Name:{4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone
CAS No.:929298-29-3
Molecular Formula:C₄₈H₇₂O₁₀Si₂
Molecular Weight:865.265
Hs Code.:

{4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone

Synonyms:{4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone

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Chemical Property of {4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone

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Technology Process of {4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone

There total 20 articles about {4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 929298-28-2
2-benzenesulfonyl-4-(tert-butyl-dimethyl-silanyloxy)-10-(tert-butyl-diphenyl-silanyloxy)-1-[8-(4-methoxy-benzyloxy)-2,2,7-trimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-5-methyl-6-triethylsilanyloxy-decan-1-one

: 929298-29-3
{4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone

Guidance literature:: 2-benzenesulfonyl-4-(tert-butyl-dimethyl-silanyloxy)-10-(tert-butyl-diphenyl-silanyloxy)-1-[8-(4-methoxy-benzyloxy)-2,2,7-trimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-5-methyl-6-triethylsilanyloxy-decan-1-one; With 2-[(p-chlorophenyl)sulfonyl]-3(p-chlorophenyl)oxaziridine; potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 1h;

With toluene-4-sulfonic acid; In tetrahydrofuran; ethylene glycol; for 2h;
DOI:10.1021/ol063083i

Reference yield:

: 8-(4-methoxy-benzyloxy)-2,2,7-trimethyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde

: 929298-29-3
{4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH₂PO₄; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

2.1: 1-chloro-N,N,2-trimethylpropenylamine / CH₂Cl₂ / 10 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: 94 percent / tetrahydrofuran; hexane / -78 °C

4.1: potassium tert-butoxide; 3-(4-chlorophenyl)-2-[(4-chlorophenyl)sulfonyl]oxaziridine / tetrahydrofuran / 1 h / 0 °C

4.2: 50 percent / p-toluenesulfonic acid / tetrahydrofuran; ethane-1,2-diol / 2 h

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-[(p-chlorophenyl)sulfonyl]-3(p-chlorophenyl)oxaziridine; 2-methyl-but-2-ene; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium tert-butylate; In tetrahydrofuran; hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol063083i

Reference yield:

: 929298-12-4
8-(4-methoxy-benzyloxy)-2,2,7-trimethyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carboxylic acid methyl ester

: 929298-29-3
{4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-hydroxy-5-methyl-tetrahydro-pyran-2-yl}-[5-hydroxy-6-hydroxymethyl-4-(4-methoxy-benzyloxy)-3-methyl-tetrahydro-pyran-2-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / lithium hydroxide / tetrahydrofuran; H₂O / 3 h / 20 °C

2.1: 1-chloro-N,N,2-trimethylpropenylamine / CH₂Cl₂ / 10 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: 94 percent / tetrahydrofuran; hexane / -78 °C

4.1: potassium tert-butoxide; 3-(4-chlorophenyl)-2-[(4-chlorophenyl)sulfonyl]oxaziridine / tetrahydrofuran / 1 h / 0 °C

4.2: 50 percent / p-toluenesulfonic acid / tetrahydrofuran; ethane-1,2-diol / 2 h

With lithium hydroxide; n-butyllithium; 2-[(p-chlorophenyl)sulfonyl]-3(p-chlorophenyl)oxaziridine; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium tert-butylate; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ol063083i