(±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione

Base Information

Chemical Name:(±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione
CAS No.:1403336-50-4
Molecular Formula:C₂₈H₂₆N₂O₄
Molecular Weight:454.525
Hs Code.:

Synonyms:(±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione

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Chemical Property of (±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione

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Technology Process of (±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione

There total 4 articles about (±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 98-54-4
para-tert-butylphenol

: 1403336-40-2
(±)-2-(2-(3-hydroxy-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione

: 1403336-50-4
(±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: (±)-2-(2-(3-hydroxy-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione; With bismuth(lll) trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 ℃; for 0.0833333h;

para-tert-butylphenol; In 1,2-dichloro-ethane; at 20 - 80 ℃; for 7h; Reagent/catalyst; regioselective reaction;
DOI:10.1039/c4ob01264j

Reference yield:

: 85-44-9
phthalic anhydride

: 1403336-50-4
(±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile; water / 0 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; cerium(III) chloride heptahydrate / 1 h

3.1: bismuth(lll) trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.08 h / 20 °C

3.2: 7 h / 20 - 80 °C

With bismuth(lll) trifluoromethanesulfonate; cerium(III) chloride heptahydrate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In water; 1,2-dichloro-ethane; acetonitrile; 3.1: |Friedel-Crafts Alkylation / 3.2: |Friedel-Crafts Alkylation;
DOI:10.1039/c4ob01264j

Reference yield:

: 15741-71-6
N-phthalimidotryptamine

: 1403336-50-4
(±)-2-(2-(3-(5-(tert-butyl)-2-hydroxyphenyl)-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; cerium(III) chloride heptahydrate / acetonitrile / 1 h / 0 °C / Inert atmosphere

2.1: bismuth(lll) trifluoromethanesulfonate / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 - 45 °C / Inert atmosphere

With bismuth(lll) trifluoromethanesulfonate; cerium(III) chloride heptahydrate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; acetonitrile; 2.2: |Friedel-Crafts Alkylation;
DOI:10.1039/c2cc35283d