1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Base Information

Chemical Name:1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea
CAS No.:1571073-56-7
Molecular Formula:C₃₃H₃₂N₈O₃Si
Molecular Weight:616.754
Hs Code.:

Synonyms:1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Suppliers and Price of 1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

There total 6 articles about 1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379401-24-7
4-((4-aminonaphthalen-1-yl)oxy)-N-phenylpyrimidin-2-amine

: 1571073-79-4
1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid

: 1571073-56-7
1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: 1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

4-((4-aminonaphthalen-1-yl)oxy)-N-phenylpyrimidin-2-amine; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

: 1571073-77-2
ethyl 1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylate

: 1571073-56-7
1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; ethanol / 3 h / 20 °C

2.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 100 °C

With ethanol; diphenyl phosphoryl azide; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 163105-89-3,600726-67-8
2-methoxy-pyridine-5-boronic acid

: 1571073-56-7
1-(1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino) pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; copper diacetate / dichloromethane / 18 h / 20 °C / Molecular sieve

2.1: sodium hydroxide; ethanol / 3 h / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 100 °C

With pyridine; ethanol; diphenyl phosphoryl azide; copper diacetate; triethylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;