4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester

Base Information

Chemical Name:4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester
CAS No.:958237-59-7
Molecular Formula:C₁₄H₁₆Cl₂O₃
Molecular Weight:303.185
Hs Code.:

Synonyms:4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester

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Chemical Property of 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester

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Technology Process of 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester

There total 4 articles about 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 103362-70-5
potassium ethyl methylmalonate

: 2-(2,6-dichloro-phenyl)-1-imidazol-1-yl-propan-1-one

: 958237-59-7
4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester

Guidance literature:: potassium ethyl methylmalonate; With triethylamine; magnesium chloride; In acetonitrile; at 20 ℃;

2-(2,6-dichloro-phenyl)-1-imidazol-1-yl-propan-1-one; In acetonitrile; Heating;

With hydrogenchloride; In acetonitrile; at 20 ℃; Further stages.;
DOI:10.1021/jm070811e

Reference yield:

: 2012-78-4
2-(2,6-dichlorophenyl)propionic acid

: 103362-70-5
potassium ethyl methylmalonate

: 958237-59-7
4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester

Guidance literature:: potassium ethyl methylmalonate; With triethylamine; magnesium chloride; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

2-(2,6-dichlorophenyl)propionic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 20 ℃; for 14h; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.5b01979

Reference yield:

: 6575-24-2
2-(2,6-dichlorophenyl)acetic acid

: 958237-59-7
4-(2,6-dichlorophenyl)-2-methyl-3-oxo-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / 0.5 h / -78 - -10 °C / Inert atmosphere

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: triethylamine; magnesium chloride / acetonitrile / 1 h / 20 °C / Inert atmosphere

2.2: 14 h / 20 °C / Inert atmosphere; Reflux

With N,N,N,N,N,N-hexamethylphosphoric triamide; triethylamine; magnesium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01979