(2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid

Base Information

• Chemical Name: (2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid
• CAS No.: 1292306-74-1
• Molecular Formula: C₂₃H₂₂F₆N₂O₄
• Molecular Weight: 504.429

Synonyms:(2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid

Chemical Property of (2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid

There total 5 articles about (2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C24H24F6N2O4 → (2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid (1292306-74-1)

Guidance literature:

With sodium thioethylate; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1016/j.bmcl.2016.03.078

Reference yield:

C19H22F3NO5 (1000894-33-6) → (2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid (1292306-74-1)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; palladium on activated charcoal / methanol / 23 °C

2: trimethylsilyl iodide / dichloromethane / 23 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 23 °C

4: sodium thioethylate / N,N-dimethyl-formamide / 80 °C

With trimethylsilyl iodide; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; sodium thioethylate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2016.03.078

Reference yield:

C19H24F3NO5 → (2R,3S)-2-propyl-1-(4-(trifluoromethyl)nicotinoyl)-3-(4-(trifluoromethyl)phenoxy)piperidine-3-carboxylic acid (1292306-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trimethylsilyl iodide / dichloromethane / 23 °C

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 23 °C

3: sodium thioethylate / N,N-dimethyl-formamide / 80 °C

With trimethylsilyl iodide; N-ethyl-N,N-diisopropylamine; HATU; sodium thioethylate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2016.03.078

upstream raw materials:

C₁₉H₂₂F₃NO₅

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