(R)-N⁵-(o-nitrophenylsulfonyl)-N⁸-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane

Base Information

• Chemical Name: (R)-N⁵-(o-nitrophenylsulfonyl)-N⁸-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane
• CAS No.: 932032-30-9
• Molecular Formula: C₁₉H₃₀IN₃O₆S
• Molecular Weight: 555.434
• Mol file: 932032-30-9.mol

Synonyms:(R)-N⁵-(o-nitrophenylsulfonyl)-N⁸-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane

Chemical Property of (R)-N⁵-(o-nitrophenylsulfonyl)-N⁸-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N⁵-(o-nitrophenylsulfonyl)-N⁸-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane

There total 4 articles about (R)-N⁵-(o-nitrophenylsulfonyl)-N⁸-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N5-(o-nitrophenylsulfonyl)-N8-(tert-butyloxycarbonyl)-8-amino-5-aza-1-chlorononane → (R)-N5-(o-nitrophenylsulfonyl)-N8-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane (932032-30-9)

Guidance literature:

With sodium iodide; In acetone; for 27h; Heating;

DOI:10.1016/j.tet.2006.12.065

Reference yield:

(R)-N1-(o-nitrophenylsulfonyl)-N3-(tert-butyloxycarbonyl)-1,3-diaminobutane (875680-89-0) → (R)-N5-(o-nitrophenylsulfonyl)-N8-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane (932032-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 20 h / 20 °C

2: 7.5 g / NaI / acetone / 27 h / Heating

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.tet.2006.12.065

Reference yield:

(3-amino-1(R)-methylpropyl)carbamic acid, 1,1-dimethylethyl ester (170367-69-8,177489-90-6) → (R)-N5-(o-nitrophenylsulfonyl)-N8-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane (932032-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: K₂CO₃ / dimethylformamide / 20 h / 20 °C

3: 7.5 g / NaI / acetone / 27 h / Heating

With potassium carbonate; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.tet.2006.12.065

upstream raw materials:

(R)-N¹-(o-nitrophenylsulfonyl)-N³-(tert-butyloxycarbonyl)-1,3-diaminobutane

(2-cyano-1(R)-methylethyl)carbamic acid, 1,1-dimethylethyl ester

(3-amino-1(R)-methylpropyl)carbamic acid, 1,1-dimethylethyl ester

Downstream raw materials:

(R)-N¹²-(tert-butyloxycarbonyl)-N⁹-(o-nitrophenylsulfonyl)-1,12-diamino-4,9-diazatridecane