Technology Process of Fmoc-(S)-β2-HVal-(S)-β3-HPhe-OH
There total 7 articles about Fmoc-(S)-β2-HVal-(S)-β3-HPhe-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; (S)-3-((S)-2-Aminomethyl-3-methyl-butyrylamino)-4-phenyl-butyric acid;
With
sodium carbonate;
In
1,4-dioxane; water;
for 1h;
sonification;
In
1,4-dioxane; water;
at 20 ℃;
for 24h;
DOI:10.1002/hlca.200390133
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Et3N; i-BuOCOCl / tetrahydrofuran / 0.5 h / -25 °C
1.2: 70 percent / tetrahydrofuran; diethyl ether / 16 h
2.1: 83 percent / silver benzoate; Et3N / tetrahydrofuran / 5 h / -25 - 20 °C
3.1: TFA / CH2Cl2 / 2 h / 0 - 20 °C
4.1: NMM; NMM*TFA / CHCl3 / 0.25 h / 0 °C
4.2: HOBt / CHCl3 / 0.25 h
4.3: EDC / CHCl3 / 24 h / 0 °C
5.1: 100 percent / H2 / Pd/C / methanol / 16 h / 750.06 Torr
6.1: 100 percent / TFA / CH2Cl2 / 2 h / 0 - 20 °C
7.1: Na2CO3 / dioxane; H2O / 1 h / sonification
7.2: 82 percent / dioxane; H2O / 24 h / 20 °C
With
4-methyl-morpholine; NMM*TFA; hydrogen; silver benzoate; sodium carbonate; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water;
DOI:10.1002/hlca.200390133
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 83 percent / silver benzoate; Et3N / tetrahydrofuran / 5 h / -25 - 20 °C
2.1: TFA / CH2Cl2 / 2 h / 0 - 20 °C
3.1: NMM; NMM*TFA / CHCl3 / 0.25 h / 0 °C
3.2: HOBt / CHCl3 / 0.25 h
3.3: EDC / CHCl3 / 24 h / 0 °C
4.1: 100 percent / H2 / Pd/C / methanol / 16 h / 750.06 Torr
5.1: 100 percent / TFA / CH2Cl2 / 2 h / 0 - 20 °C
6.1: Na2CO3 / dioxane; H2O / 1 h / sonification
6.2: 82 percent / dioxane; H2O / 24 h / 20 °C
With
4-methyl-morpholine; NMM*TFA; hydrogen; silver benzoate; sodium carbonate; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water;
DOI:10.1002/hlca.200390133
