2-BROMO-5-NITRO-6-PICOLINE

Base Information

• Chemical Name: 2-BROMO-5-NITRO-6-PICOLINE
• CAS No.: 22282-96-8
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.022
• Hs Code.: 2933399090
• Mol file: 22282-96-8.mol

Synonyms:6-Bromo-2-methyl-3-nitropyridine;2-Picoline,6-bromo-3-nitro- (8CI);

Chemical Property of 2-BROMO-5-NITRO-6-PICOLINE

Chemical Property:

• Appearance/Colour: Yellow solid
• Vapor Pressure: 0.0093mmHg at 25°C
• Melting Point: 69-70 °C
• Refractive Index: 1.599
• Boiling Point: 274 °C at 760 mmHg
• PKA: -2.52±0.10(Predicted)
• Flash Point: 119.5 °C
• PSA: 58.71000
• Density: 1.709 g/cm³
• LogP: 2.58390
• Storage Temp.: Refrigerator
• Solubility.: Chloroform

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-6-methyl-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, Xi
• Hazard Codes: T,Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-NITRO-6-PICOLINE

There total 2 articles about 2-BROMO-5-NITRO-6-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methyl-5-nitropyridin-2-ol (28489-45-4) → 6-bromo-2-methyl-3-nitro-pyridine (22282-96-8) + 2,3-dibromo-6-methyl-5-nitro-pyridine

Guidance literature:

With bromine; phosphorus tribromide;

DOI:10.1021/ja01627a078

Reference yield:

6-methyl-5-nitropyridin-2-ol (28489-45-4) → 6-bromo-2-methyl-3-nitro-pyridine (22282-96-8)

Guidance literature:

With phosphorus(V) oxybromide; In 1,1,2,2-tetrachloroethane; for 4h; Heating;

DOI:10.1016/S0960-894X(03)00017-9

Reference yield: 95.0%

6-bromo-2-methyl-3-nitro-pyridine (22282-96-8) + 3-METHOXYBENZYLAMINE (5071-96-5) → N-(3-methoxybenzyl)-6-methyl-5-nitropyridin-2-amine

Guidance literature:

With triethylamine; In isopropyl alcohol; Reflux;

DOI:10.1039/c9ob00511k

upstream raw materials:

6-methyl-5-nitropyridin-2-ol

Downstream raw materials:

(1H-pyrrolo[3,2-b]pyridin-5-yl)methanamine

2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanone

5-bromo-2-(2-chloro-6-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine