5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide

Base Information

• Chemical Name: 5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide
• CAS No.: 219986-58-0
• Molecular Formula: C₁₁H₁₀F₃N₃OS
• Molecular Weight: 289.281

Synonyms:5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide

Chemical Property of 5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide

Chemical Property:

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Technology Process of 5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide

There total 3 articles about 5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

thiosemicarbazide (79-19-6) + 4-methoxy-4-phenyl-1,1,1-trifluorobut-3-en-2-one → 5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide (219986-58-0)

Guidance literature:

In methanol; at 40 - 45 ℃; for 20h;

DOI:10.1016/S0022-1139(98)00242-5

Reference yield: 65.0%

1-Phenyl-4,4,4-trifluorobutane-1,3-dione (326-06-7) + thiosemicarbazide (79-19-6) → 5-phenyl-3-trifluoromethylpyrazol-1-thiocarboxamide (1337556-73-6) + 5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide (219986-58-0)

Guidance literature:

In ethanol; for 6h; regioselective reaction; Reflux;

DOI:10.1016/j.jfluchem.2011.07.029

Reference yield:

1-Phenyl-4,4,4-trifluorobutane-1,3-dione (326-06-7) + thiosemicarbazide (79-19-6) → C11H10F3N3OS + 5-hydroxy-3-phenyl-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide (219986-58-0)

Guidance literature:

In ethanol; for 12h;

DOI:10.1021/acs.jmedchem.7b00941

upstream raw materials:

thiosemicarbazide

1-Phenyl-4,4,4-trifluorobutane-1,3-dione

Downstream raw materials:

3-phenyl-5-(trifluoromethyl)-1H-pyrazole

1-methyl-3-phenyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-ol

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