2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene

Base Information

• Chemical Name: 2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene
• CAS No.: 114532-40-0
• Molecular Formula: C₂₁H₂₂O₅S
• Molecular Weight: 386.469
• Mol file: 114532-40-0.mol

Synonyms:2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene

Chemical Property of 2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene

There total 3 articles about 2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(hydroxymethyl)-2-methyl-1,4,5-trimethoxynaphthalene (114506-35-3) → 2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene (114532-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: PBr₃ / CH₂Cl₂ / 0.17 h / -5 °C

2: dimethylformamide / 1 h / Ambient temperature

With phosphorus tribromide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00248a014

Reference yield:

3-(ethoxcarbonyl)-2-methyl-1,4,5-trimethoxynaphthalene (114506-34-2) → 2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene (114532-40-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / LiAlH₄ / tetrahydrofuran / 1 h / 25 °C

2: PBr₃ / CH₂Cl₂ / 0.17 h / -5 °C

3: dimethylformamide / 1 h / Ambient temperature

With lithium aluminium tetrahydride; phosphorus tribromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00248a014

Reference yield:

sodium benzenesulfonate (873-55-2) + 3-(bromomethyl)-1,4,5-trimethoxy-2-methylnaphthalene (114506-36-4) → 2-methyl-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene (114532-40-0)

Guidance literature:

In N,N-dimethyl-formamide; for 1h; Yield given; Ambient temperature;

DOI:10.1021/jo00248a014

upstream raw materials:

sodium benzenesulfonate

3-(bromomethyl)-1,4,5-trimethoxy-2-methylnaphthalene

3-(hydroxymethyl)-2-methyl-1,4,5-trimethoxynaphthalene

3-(ethoxcarbonyl)-2-methyl-1,4,5-trimethoxynaphthalene

Downstream raw materials:

2-(bromomethyl)-3-<(phenylsulfonyl)methyl>-1,4,5-trimethoxynaphthalene