Technology Process of rac-4-(benzyloxy)-3-methylbutan-2-one
There total 10 articles about rac-4-(benzyloxy)-3-methylbutan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
under 750.075 Torr;
Schlenk technique;
DOI:10.1016/j.tet.2018.05.026
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 92 percent / BF3*OEt2 / CH2Cl2 / 0 °C
2: 89 percent / LiAlH4 / diethyl ether / 0 deg C to RT
3: 86 percent / Heating
4: 83 percent / POCl3, Et3N / tetrahydrofuran / 0 °C
5: 88 percent / LDA / tetrahydrofuran / -78 °C
6: 78 percent / LDA / tetrahydrofuran / 1 h / -78 °C
7: 78 percent / conc. aq. HCl / tetrahydrofuran / 0.17 h / 0 °C
With
hydrogenchloride; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; triethylamine; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/0040-4039(96)00312-7
