carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester

Base Information

• Chemical Name: carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester
• CAS No.: 1350551-81-3
• Molecular Formula: C₃₃H₃₈F₂N₈O₉
• Molecular Weight: 728.71

Synonyms:carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester

Chemical Property of carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester

There total 21 articles about carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbonic acid 5-{(R)-(4-carbamimidoylphenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester 2-fluoro-1,1-dimethylethyl ester acetate (1350552-40-7) + n-propyl 4-nitrophenyl carbonate (67036-12-8) → carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester (1350551-81-3)

Guidance literature:

With pyridine; at 20 ℃;

Reference yield:

2-Fluoro-3-hydroxy-5-methoxybenzaldehyde (883576-31-6) → carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester (1350551-81-3)

Guidance literature:

Multi-step reaction with 15 steps

1.1: guanidine hydrochloride / methanol / 1.5 h / 40 °C / Inert atmosphere

1.2: 22 h / 40 °C

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 13.5 h / 70 °C / Inert atmosphere

3.1: water; diammonium sulfide / tetrahydrofuran; methanol / 20 °C

4.1: acetonitrile / 0.83 h / 20 °C / Cooling

5.1: 2,4,6-trimethyl-pyridine / ethyl acetate; toluene / 85 °C

6.1: triethylamine / toluene / 4.17 h / 50 - 110 °C

7.1: acetic acid; 2-picoline borane complex / water; methanol / 24 h / 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 23.5 h / 20 °C

8.2: 0.33 h

9.1: acetyl chloride; methanol / 18.5 h / 5 - 10 °C

9.2: 18 h / 10 - 20 °C

9.3: 18 h / 20 °C

10.1: triethylamine / methanol / 0.25 h / 60 °C

10.2: 23 h / 0 - 20 °C

11.1: hydrogenchloride / ethanol; water; methanol / 20 °C

12.1: potassium carbonate / dimethyl sulfoxide / 96 h / 20 °C

13.1: rubidium carbonate / N,N-dimethyl acetamide / 1 h / 85 °C / Inert atmosphere

14.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 45 °C / Inert atmosphere

15.1: pyridine / 20 °C

With rubidium carbonate; pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; methanol; diammonium sulfide; 2-picoline borane complex; water; guanidine hydrochloride; potassium carbonate; acetic acid; triethylamine; acetyl chloride; sodium iodide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

1-fluoro-4-methoxybenzene (459-60-9) → carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester (1350551-81-3)

Guidance literature:

Multi-step reaction with 18 steps

1.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / hexane; tetrahydrofuran / -70 °C / Inert atmosphere

1.2: 1 h

1.3: -10 - 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

3.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / hexane; tetrahydrofuran / 3 h / -72 - -56 °C / Inert atmosphere

3.3: 10 - 20 °C

4.1: guanidine hydrochloride / methanol / 1.5 h / 40 °C / Inert atmosphere

4.2: 22 h / 40 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 13.5 h / 70 °C / Inert atmosphere

6.1: water; diammonium sulfide / tetrahydrofuran; methanol / 20 °C

7.1: acetonitrile / 0.83 h / 20 °C / Cooling

8.1: 2,4,6-trimethyl-pyridine / ethyl acetate; toluene / 85 °C

9.1: triethylamine / toluene / 4.17 h / 50 - 110 °C

10.1: acetic acid; 2-picoline borane complex / water; methanol / 24 h / 20 °C

11.1: sodium hydroxide; water / tetrahydrofuran; methanol / 23.5 h / 20 °C

11.2: 0.33 h

12.1: acetyl chloride; methanol / 18.5 h / 5 - 10 °C

12.2: 18 h / 10 - 20 °C

12.3: 18 h / 20 °C

13.1: triethylamine / methanol / 0.25 h / 60 °C

13.2: 23 h / 0 - 20 °C

14.1: hydrogenchloride / ethanol; water; methanol / 20 °C

15.1: potassium carbonate / dimethyl sulfoxide / 96 h / 20 °C

16.1: rubidium carbonate / N,N-dimethyl acetamide / 1 h / 85 °C / Inert atmosphere

17.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 45 °C / Inert atmosphere

18.1: pyridine / 20 °C

With rubidium carbonate; pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; methanol; diammonium sulfide; n-butyllithium; 2-picoline borane complex; N,N,N',N'',N'''-pentamethyldiethylenetriamine; water; guanidine hydrochloride; potassium carbonate; acetic acid; triethylamine; acetyl chloride; sodium iodide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

1-fluoro-4-methoxybenzene

2-Fluoro-3-hydroxy-5-methoxybenzaldehyde

carbonic acid 2-{3-[(4-cyanophenylamino)-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]-triazol-3-yl)methyl]-2-fluoro-5-methoxyphenoxy}ethyl ester methyl ester

carbonic acid 5-{(R)-(4-carbamimidoylphenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester 2-fluoro-1,1-dimethylethyl ester acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1350551-81-3 carbonic acid 5-{(R)-(4-{amino[2-propoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester2-fluoro-1,l-dimethylethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send