Z-ARG-PNA HCL

Base Information

• Chemical Name: Z-ARG-PNA HCL
• CAS No.: 59188-53-3
• Molecular Formula: C20H24 N6 O5 . Cl H
• Molecular Weight: 464.9
• Mol file: 59188-53-3.mol

Synonyms:L-ZAPA;N-ALPHA-BENZYLOXYCARBONYL-L-ARGININE-P-NITROANILIDE HYDROCHLORIDE;Z-L-ARGININE P-NITROANILIDE HYDROCHLORIDE;Z-L-ARGININE-4-NITROANILIDE HYDROCHLORIDE;Z-L-ARG-PNA HCL;Z-ARG-PNA HCL;Z-ARGININE-PNA HCL;N-A-cbz-L-arginine P-nitroanilide*hydrochloride

Chemical Property of Z-ARG-PNA HCL

Chemical Property:

• PSA: 175.15000
• LogP: 5.07160
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

Z-L-Arg-pNAhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Substrate for trypsin.

Technology Process of Z-ARG-PNA HCL

There total 3 articles about Z-ARG-PNA HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Z-Arg-OH hydrochloride (56672-63-0) + 4-nitro-aniline (100-01-6,104810-17-5) → Z-L-Arg-pNA*HCl (59188-53-3)

Guidance literature:

With pyridine; trichlorophosphate; at -15 ℃;

DOI:10.1016/0040-4020(95)00671-T

Reference yield: 95.0%

Z-Arg-OH (1234-35-1) + 4-nitro-aniline (100-01-6,104810-17-5) → Z-L-Arg-pNA*HCl (59188-53-3)

Guidance literature:

With pyridine; trichlorophosphate; for 0.5h;

Reference yield: 94.0%

Z-Arg-OH hydrochloride (56672-63-0) + N,N'-bis(4-nitrophenyl)phospheneimidous amide (134393-23-0) → Z-L-Arg-pNA*HCl (59188-53-3)

Guidance literature:

With pyridine; at 40 ℃; for 4h;

DOI:10.1246/bcsj.64.1422

upstream raw materials:

Z-Arg-OH hydrochloride

N,N'-bis(4-nitrophenyl)phospheneimidous amide

Z-Arg-OH

4-nitro-aniline

Refernces

• 1、 Oyamada, Hidekazu,Saito, Takashi,Inaba, Shinsaku,Ueki, Masaaki. "Reinvestigation of the Phosphazo Method and Synthesis of N-(t-Butoxycarbonyl)-L-arginine p-Nitroanilide and a Chromogenic Enzyme Substrate for the Factor Xa". . p. 1422 - 1424. Retrieved 2007/10/02.