2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide
CAS No.:1308256-61-2
Molecular Formula:C₁₂H₁₀F₃N₃O₂
Molecular Weight:285.226
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide

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Technology Process of 2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide

There total 4 articles about 2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1308256-60-1
3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)aniline

: 407-25-0
trifluoroacetic anhydride

: 1308256-61-2
2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; for 16h;

Reference yield:

: 1877-73-2
3-nitro-benzeneacetic acid

: 1308256-61-2
2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

2: acetic acid / 3 h / Reflux

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

4: triethylamine / dichloromethane / 16 h

With hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 361193-21-7
2-(3-nitrophenyl)acetic hydrazide

: 1308256-61-2
2,2,2-trifluoro-N-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 3 h / Reflux

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: triethylamine / dichloromethane / 16 h

With hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;