(S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate

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Chemical Name:(S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate
CAS No.:1376616-08-8
Molecular Formula:C₂₉H₃₁N₅O₆
Molecular Weight:545.595
Hs Code.:

Synonyms:(S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate

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Chemical Property of (S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate

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Technology Process of (S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate

There total 6 articles about (S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1376616-07-7
(S)-benzyl 5-acetoxy-4-aminopentanoate

: 137281-39-1
4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

: 1376616-08-8
(S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate

Guidance literature:: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

(S)-benzyl 5-acetoxy-4-aminopentanoate; With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 79069-62-8
benzyl (S)-4-(t-butyloxycarbonylamino)-5-hydroxypentanoate

: 1376616-08-8
(S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 1 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 20 °C

3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / N,N-dimethyl-formamide / 3 h / 20 °C

3.2: 20 °C

With 4-methyl-morpholine; dmap; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 1376616-08-8
(S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; 4-methyl-morpholine / tetrahydrofuran / 0.42 h / -10 °C / Inert atmosphere

1.2: 1.17 h / 0 °C

2.1: dmap / dichloromethane / 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 20 °C

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / N,N-dimethyl-formamide / 3 h / 20 °C

4.2: 20 °C

With 4-methyl-morpholine; dmap; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; chloroformic acid ethyl ester; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;