Technology Process of carbonic acid 3-(2,5-dimethyl-phenyl)-8-methoxy-1-methoxy-methoxy-2-oxo-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester ethyl ester
There total 7 articles about carbonic acid 3-(2,5-dimethyl-phenyl)-8-methoxy-1-methoxy-methoxy-2-oxo-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / Cooling with ice; Reflux
1.2: pH 7 - 8
2.1: thionyl chloride / 48 h / 0 - 10 °C / Reflux
3.1: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
4.2: 2.5 h / 0 - 20 °C
4.3: 2.5 h / 20 °C
5.1: triethylamine / dmap / tetrahydrofuran / 2 h / 0 - 20 °C
With
thionyl chloride; sulfuric acid; sodium hydride; sodium hydrogencarbonate; triethylamine;
dmap;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium dihydrogenphosphate / water / 0 - 20 °C
2.1: sulfuric acid / Cooling with ice; Reflux
2.2: pH 7 - 8
3.1: thionyl chloride / 48 h / 0 - 10 °C / Reflux
4.1: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 0 - 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
5.2: 2.5 h / 0 - 20 °C
5.3: 2.5 h / 20 °C
6.1: triethylamine / dmap / tetrahydrofuran / 2 h / 0 - 20 °C
With
potassium dihydrogenphosphate; thionyl chloride; sulfuric acid; sodium hydride; sodium hydrogencarbonate; triethylamine;
dmap;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydroxylamine hydrochloride; triethylamine / methanol / 1.5 h / Reflux
2.1: potassium dihydrogenphosphate / water / 0 - 20 °C
3.1: sulfuric acid / Cooling with ice; Reflux
3.2: pH 7 - 8
4.1: thionyl chloride / 48 h / 0 - 10 °C / Reflux
5.1: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 0 - 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
6.2: 2.5 h / 0 - 20 °C
6.3: 2.5 h / 20 °C
7.1: triethylamine / dmap / tetrahydrofuran / 2 h / 0 - 20 °C
With
potassium dihydrogenphosphate; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; triethylamine;
dmap;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;
