4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

Base Information

Chemical Name:4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide
CAS No.:1208342-39-5
Molecular Formula:C₂₄H₁₆Cl₂F₃IN₄O
Molecular Weight:631.223
Hs Code.:

Synonyms:4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

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Chemical Property of 4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

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Technology Process of 4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

There total 6 articles about 4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1208342-20-4
4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

: 1208342-39-5
4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

Guidance literature:: With tert.-butylnitrite; iodoform; In chloroform; at 20 ℃;

Reference yield:

: 103204-69-9
4-acetylamino-2-methylbenzoic acid

: 1208342-39-5
4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 3 h / Reflux

1.2: Cooling with ice

2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

2.2: 2 h / 0 - 20 °C

2.3: pH 8 - 9 / Cooling with ice

3.1: triethylamine / ethanol / 80 °C

4.1: water; sodium hydroxide / ethanol / 48 h / 20 °C

4.2: pH 3 - 4

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

6.1: tert.-butylnitrite; iodoform / chloroform / 20 °C

With hydrogenchloride; tert.-butylnitrite; iodoform; sulfuric acid; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; sodium nitrite; In ethanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1208351-36-3
methyl 4-hydrazino-2-methylbenzoate

: 1208342-39-5
4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol / 80 °C

2.1: water; sodium hydroxide / ethanol / 48 h / 20 °C

2.2: pH 3 - 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

4.1: tert.-butylnitrite; iodoform / chloroform / 20 °C

With tert.-butylnitrite; iodoform; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; chloroform; N,N-dimethyl-formamide;