N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide

Base Information

Chemical Name:N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide
CAS No.:1311982-87-2
Molecular Formula:C₂₅H₃₂N₈O₂
Molecular Weight:476.581
Hs Code.:

Synonyms:N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide

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Chemical Property of N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide

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Technology Process of N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide

There total 4 articles about N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 88192-19-2
3-azidopropylamine

: 1311982-91-8
4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)phenoxy)butanoic acid

: 1311982-87-2
N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide

Guidance literature:: 4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)phenoxy)butanoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

3-azidopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 36h; Inert atmosphere;
DOI:10.1021/ja200212b

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1311982-87-2
N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

2.1: nitrobenzene / 48 h / 140 °C

3.1: potassium hydroxide / ethanol; water / 60 °C

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

4.2: 36 h / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; water; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1021/ja200212b

Reference yield:

: 92991-64-5
ethyl 4-(4-formylphenoxy)butyrate

: 1311982-87-2
N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole-2-yl)phenoxy)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitrobenzene / 48 h / 140 °C

2.1: potassium hydroxide / ethanol; water / 60 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

3.2: 36 h / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; water; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1021/ja200212b