2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide

Base Information

Chemical Name:2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide
CAS No.:1559062-29-1
Molecular Formula:C₂₈H₃₀IN₃O₂
Molecular Weight:567.47
Hs Code.:

Synonyms:2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide

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Chemical Property of 2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide

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Technology Process of 2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide

There total 4 articles about 2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 9-epi-9-amino-9-deoxyquinine

: 52107-93-4
2-iodo-3-methylbenzoyl chloride

: 1559062-29-1
2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1039/c4ob00027g

Reference yield:

: 130-95-0
quinine

: 1559062-29-1
2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

1.2: 4 h / 0 - 5 °C

2.1: sodium azide / N,N-dimethyl-formamide / 20 h / 60 °C

3.1: triphenylphosphine / tetrahydrofuran / 4 h / 60 °C

3.2: 10 h / 20 °C

4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.1: |Staudinger Azide Reduction;
DOI:10.1039/c4ob00027g

Reference yield:

: 249731-47-3
quinine 9O-methanesulfonate

: 1559062-29-1
2-iodo-N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 h / 60 °C

2.1: triphenylphosphine / tetrahydrofuran / 4 h / 60 °C

2.2: 10 h / 20 °C

3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: |Staudinger Azide Reduction;
DOI:10.1039/c4ob00027g