(R)-2,2,2-trichloro-1-phenylethyl (R)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate

Base Information

• Chemical Name: (R)-2,2,2-trichloro-1-phenylethyl (R)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate
• CAS No.: 1374003-71-0
• Molecular Formula: C₁₇H₁₅Cl₄NO₃
• Molecular Weight: 423.123
• Mol file: 1374003-71-0.mol

Synonyms:(R)-2,2,2-trichloro-1-phenylethyl (R)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate

Chemical Property of (R)-2,2,2-trichloro-1-phenylethyl (R)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2,2,2-trichloro-1-phenylethyl (R)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate

There total 2 articles about (R)-2,2,2-trichloro-1-phenylethyl (R)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-((R)-1-phenyl-2,2,2-trichloroethyl) 2-(4-chlorophenyl)aziridine-1-carboxylate (1374003-35-6) → (R)-2,2,2-trichloro-1-phenylethyl (R)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate (1374003-71-0) + (R)-2,2,2-trichloro-1-phenylethyl (S)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate (1374003-76-5)

Guidance literature:

With boron trifluoride diethyl etherate; water; In diethyl ether; acetonitrile; at 20 ℃; for 0.25h; optical yield given as %de; diastereoselective reaction;

DOI:10.1016/j.tet.2012.02.044

Reference yield:

4-vinylbenzyl chloride (1073-67-2,24991-47-7) + (R)-2,2,2-trichloro-1-phenylethyl N-tosyloxycarbamate → (R)-2,2,2-trichloro-1-phenylethyl (R)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate (1374003-71-0) + (R)-2,2,2-trichloro-1-phenylethyl (S)-2-(4-chlorophenyl)-2-hydroxyethylcarbamate (1374003-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(actonitrile)copper(I) hexafluorophosphate; (4R,4'R)-2,2'-(propane-2,2-diyl)bis(5,5-dimethyl-4-phenyl-4,5-dihydrooxazole); potassium carbonate / acetonitrile / 14 h / 23 °C / Inert atmosphere; Molecular sieve

2: boron trifluoride diethyl etherate; water / diethyl ether; acetonitrile / 0.25 h / 20 °C

With tetrakis(actonitrile)copper(I) hexafluorophosphate; (4R,4'R)-2,2'-(propane-2,2-diyl)bis(5,5-dimethyl-4-phenyl-4,5-dihydrooxazole); boron trifluoride diethyl etherate; water; potassium carbonate; In diethyl ether; acetonitrile;

DOI:10.1016/j.tet.2012.02.044

upstream raw materials:

4-vinylbenzyl chloride

(S)-((R)-1-phenyl-2,2,2-trichloroethyl) 2-(4-chlorophenyl)aziridine-1-carboxylate