5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide

Base Information

Chemical Name:5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide
CAS No.:201150-74-5
Molecular Formula:C₂₃H₂₇ClN₂O₅
Molecular Weight:446.931
Hs Code.:

Synonyms:5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide

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Chemical Property of 5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide

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Technology Process of 5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide

There total 3 articles about 5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1125-60-6
isoquinolin-5-ylamine

: 201150-74-5
5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 6.45 g / conc. H₂SO₄; H₂ / platinum oxide / acetic acid / 20 h / 2844.31 Torr

2: 30 percent / 3M NaOH / dioxane / 18 h / 25 °C

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; HOBT / dimethylformamide; CH₂Cl₂ / 18 h / 25 °C

With sodium hydroxide; sulfuric acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum(IV) oxide; In 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide; 1: Reduction / 2: Acylation / 3: Acylation;
DOI:10.1016/S0968-0896(00)00149-8

Reference yield:

: 23053-81-8
5-chloro-2,4-dimethoxybenzoic Acid

: 201150-73-4
5-amino-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline

: 201150-74-5
5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 18h;
DOI:10.1016/S0968-0896(00)00149-8

Reference yield:

: 115955-90-3
1,2,3,4-tetrahydroisoquinolin-5-amine

: 201150-74-5
5-Chloro-2,4-dimethoxy-N-[2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / 3M NaOH / dioxane / 18 h / 25 °C

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; HOBT / dimethylformamide; CH₂Cl₂ / 18 h / 25 °C

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Acylation;
DOI:10.1016/S0968-0896(00)00149-8