(3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole

Base Information

• Chemical Name: (3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole
• CAS No.: 370880-07-2
• Molecular Formula: C₁₆H₁₉F₃N₂O
• Molecular Weight: 312.335

Synonyms:(3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole

Chemical Property of (3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole

Chemical Property:

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Technology Process of (3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole

There total 2 articles about (3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(3aR,6aR)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,2-c]pyrrole (370880-03-8) + trifluoroacetic anhydride (407-25-0) → (3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole (370880-07-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 45.0%

(3aS,6aS)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,4-b]pyrrole (370880-12-9) + trifluoroacetic anhydride (407-25-0) → (3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole (370880-07-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield: 100.0%

(3aR,6aR)-1-[(1R)-1-phenethyl]-5-(trifluoroacetyl)octahydropyrrolo[3,4-b]pyrrole (370880-07-2) → 2,2,2-trifluoro-1-((3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

Guidance literature:

With hydrogen; palladium(II) hydroxide; In methanol; dichloromethane; at 20 ℃;

upstream raw materials:

(3aR,6aR)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,2-c]pyrrole

trifluoroacetic anhydride

(3aS,6aS)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,4-b]pyrrole

Downstream raw materials:

tert-butyl (3aR,6aR)-5-(trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrole-1 (2H)-carboxylate

tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro-5-(cyclopropylsulfuryl)-pyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate

(R)-3-amino-1-((3aS,6aS)-5-(2-fluoro-2-methylpropionyl)-hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro5-methoxyformylpyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate

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