N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide

Base Information

Chemical Name:N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide
CAS No.:1383851-34-0
Molecular Formula:C₂₆H₂₃N₃O₄S
Molecular Weight:473.552
Hs Code.:

Synonyms:N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide

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Chemical Property of N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide

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Technology Process of N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide

There total 9 articles about N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1383851-33-9
N-[3-(4,5-dihydro-1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide

: 1383851-34-0
N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide

Guidance literature:: With [bis(acetoxy)iodo]benzene; potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 536-74-3
phenylacetylene

: 1383851-34-0
N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Sealed flask

2.1: iodine / dichloromethane / 5 h / Reflux

3.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / methanol; acetonitrile / 16 h / 80 °C

4.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 3 h / 95 °C

5.1: pyridine / dichloromethane / 16 h / 10 - 15 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

7.2: 0.33 h / 20 °C / Inert atmosphere

8.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1 h / 20 °C

9.1: dichloromethane / 0.5 h / 0 °C / Inert atmosphere

9.2: 0 - 20 °C / Inert atmosphere

10.1: [bis(acetoxy)iodo]benzene; potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; [bis(acetoxy)iodo]benzene; iodine; iron; potassium carbonate; ammonium chloride; 4-methylmorpholine N-oxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2-methoxy-4-nitro-1-(phenylethynyl)benzene

: 1383851-34-0
N-[3-(1H-imidazol-2-yl)-2-phenyl-1-benzofuran-6-yl]-N-(4-methoxybenzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: iodine / dichloromethane / 5 h / Reflux

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / methanol; acetonitrile / 16 h / 80 °C

3.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 3 h / 95 °C

4.1: pyridine / dichloromethane / 16 h / 10 - 15 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

6.2: 0.33 h / 20 °C / Inert atmosphere

7.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1 h / 20 °C

8.1: dichloromethane / 0.5 h / 0 °C / Inert atmosphere

8.2: 0 - 20 °C / Inert atmosphere

9.1: [bis(acetoxy)iodo]benzene; potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; [bis(acetoxy)iodo]benzene; iodine; iron; potassium carbonate; ammonium chloride; 4-methylmorpholine N-oxide; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;