3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester

Base Information

• Chemical Name: 3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester
• CAS No.: 218462-45-4
• Molecular Formula: C₁₇H₂₂O₄
• Molecular Weight: 290.359
• Mol file: 218462-45-4.mol

Synonyms:3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester

Chemical Property of 3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester

There total 6 articles about 3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-[1-(4-Methoxymethoxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester (218462-53-4) → 3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester (218462-45-4)

Guidance literature:

In ethanol; benzene; at 40 ℃; for 8h;

DOI:10.1002/(sici)1522-2675(19981111)81:11<2017::aid-hlca2017>3.0.co;2-p

Reference yield: 65.0%

3-[1-(4-Methoxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester (218462-54-5) → 3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester (218462-45-4)

Guidance literature:

With hydrogen bromide; In acetic anhydride; for 4h; Heating;

DOI:10.1002/(sici)1522-2675(19981111)81:11<2017::aid-hlca2017>3.0.co;2-p

Reference yield:

2-(4-methoxybenzyl)cyclohexan-1-one (37722-64-8) → 3-[1-(4-Hydroxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester (218462-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / toluene / 30 h / Heating

2: 80 percent / 2.) 10percent aq.AcOH / 144 h / 50 °C / 2.) THF, MeOH, rt, overnight

3: 65 percent / 48percent hydrobromic acid / acetic anhydride / 4 h / Heating

With hydrogen bromide; acetic acid; In acetic anhydride; toluene;

DOI:10.1002/(sici)1522-2675(19981111)81:11<2017::aid-hlca2017>3.0.co;2-p

upstream raw materials:

3-[1-(4-Methoxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester

3-[1-(4-Methoxymethoxy-benzyl)-2-oxo-cyclohexyl]-propionic acid methyl ester

2-(4-methoxybenzyl)cyclohexan-1-one

2-(4-methoxymethoxybenzyl)-1-cyclohexanone