4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide

Base Information

Chemical Name:4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide
CAS No.:1428760-94-4
Molecular Formula:C₂₁H₁₅Cl₂N₅O₂
Molecular Weight:440.288
Hs Code.:

Synonyms:4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide

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Chemical Property of 4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide

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Technology Process of 4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide

There total 9 articles about 4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 839708-50-8
2-chloro-4-(methylamino)pyrimidine-5-carbaldehyde

: 1428760-95-5
[2-chloro-4-(2-methylcarbamoylpyridin-4-yl)phenyl]acetic acid methyl ester

: 1428760-94-4
4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide;

Reference yield:

: 1428760-91-1
ethyl 2,4-dioxohexahydropyrimidine-5-carboxylate

: 1428760-94-4
4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate; N,N-diethylaniline / 105 °C

2: triethylamine / dichloromethane; tetrahydrofuran / 3 h / -78 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 5 °C

4: manganese(IV) oxide / tetrahydrofuran / 1 h / 40 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide

With manganese(IV) oxide; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 30766-03-1
4-bromo-2-picolinic acid

: 1428760-94-4
4-(3-chloro-4-(2-chloro-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / water; tetrahydrofuran; toluene / 18 h / Inert atmosphere; Reflux

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;