(4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine

Base Information

Chemical Name:(4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine
CAS No.:1231177-40-4
Molecular Formula:C₂₂H₂₀ClNS₂
Molecular Weight:397.993
Hs Code.:

Synonyms:(4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine

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Chemical Property of (4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine

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Technology Process of (4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine

There total 6 articles about (4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: {3-[1-chloro-(E)-methylidene]-3,4,4a,5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-(4-chloro-phenyl)-amine

: 108-98-5
thiophenol

: 1231177-40-4
(4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine

Guidance literature:: With trimethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1231177-40-4
(4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; magnesium / tetrahydrofuran / Reflux

1.2: 1 h / 0 - 20 °C

2.1: iodine / tetrahydrofuran / 0 - 20 °C

2.2: 0 - 20 °C

3.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

5.1: trimethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With iodine; magnesium; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; trimethylamine; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide;

Reference yield:

: 1231177-58-4
(4-chlorophenyl)-(3,4,4a, 5,6,8a-hexahydro-thiochromene-2-ylidene)-amine

: 1231177-40-4
(4-chloro-phenyl)-{3-[1-phenyl sulfanyl-(E)-methylidene]-3,4,4a, 5,6,8a-hexahydro-thiochromene-(2Z)-ylidene}-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3.1: trimethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; trimethylamine; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide;