3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide

Base Information

• Chemical Name: 3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide
• CAS No.: 603121-75-1
• Molecular Formula: C₂₃H₂₇ClN₂O₅
• Molecular Weight: 446.931
• Mol file: 603121-75-1.mol

Synonyms:3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide

Chemical Property of 3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide

There total 3 articles about 3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

3-(3-Chlorphenyl)-2-oxopropansaeure (96406-06-3) + (2S)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(methylamino)propanamide (603121-71-7) → 3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide (603121-75-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.200200705

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide (603121-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / Et₃N; BOP / tetrahydrofuran / 20 °C

2: 69 percent / HCl; H₂ / Pd/C / ethanol; H₂O / 2 h / 50 °C

3: 48 percent / Et₃N; BOP / tetrahydrofuran / 20 °C

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;

DOI:10.1002/ejoc.200200705

Reference yield:

benzyl (1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl(methyl)carbamate (603121-67-1) → 3-(3-chlorophenyl)-N-[(1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl]-N-methyl-2-oxopropanamide (603121-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / HCl; H₂ / Pd/C / ethanol; H₂O / 2 h / 50 °C

2: 48 percent / Et₃N; BOP / tetrahydrofuran / 20 °C

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;

DOI:10.1002/ejoc.200200705

upstream raw materials:

3-(3-Chlorphenyl)-2-oxopropansaeure

(2S)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(methylamino)propanamide

2-(3,4-dimethoxyphenyl)-ethylamine

benzyl (1S)-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl(methyl)carbamate

Refernces