isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

Base Information

Chemical Name:isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate
CAS No.:1350893-56-9
Molecular Formula:C₃₁H₄₇O₆PSi
Molecular Weight:574.77
Hs Code.:

Synonyms:isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

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Chemical Property of isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

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Technology Process of isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

There total 8 articles about isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1660-94-2
Tetraethyl methylenediphosphonate

: 1334217-97-8
isopropyl 7-(tert-butyldiphenylsilyloxy)-2-oxoheptanoate

: 1334218-00-6
isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

: 1350893-56-9
isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

Guidance literature:: Tetraethyl methylenediphosphonate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

isopropyl 7-(tert-butyldiphenylsilyloxy)-2-oxoheptanoate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.75h; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.03.071

Reference yield:

: 1334217-94-5
C₂₆H₃₅ClO₄Si

: 1334218-00-6
isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

: 1350893-56-9
isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / diethyl ether; toluene / 3.5 h / -60 - -20 °C / Inert atmosphere

2.1: sodium hydrogensulfite / diethyl ether; water / 0.08 h / Inert atmosphere

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2.75 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; iodine; sodium hydrogensulfite; magnesium; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; water; toluene;
DOI:10.1016/j.bmcl.2011.03.071

Reference yield:

: C₂₆H₃₅IO₄Si

: 1334218-00-6
isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

: 1350893-56-9
isopropyl 7-(tert-butyldiphenylsilyloxy)-2-(diethoxyphosphonomethenyl)heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogensulfite / diethyl ether; water / 0.08 h / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2.75 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hydrogensulfite; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1016/j.bmcl.2011.03.071