N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide

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Chemical Name:N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide
CAS No.:75792-57-3
Molecular Formula:C₃₆H₄₆N₆O₆
Molecular Weight:658.798
Hs Code.:

N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide

Synonyms:N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide

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Chemical Property of N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide

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Technology Process of N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide

There total 13 articles about N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 75792-44-8
benzyl 4-amino-1,3,5-trimethylpyrrole-2-carboxylate

: 4-[(4-tert-Butoxycarbonylamino-1,3,5-trimethyl-1H-pyrrole-2-carbonyl)-amino]-1,3,5-trimethyl-1H-pyrrole-2-carboxylic acid benzotriazol-1-yl ester

: 75792-57-3
N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide

Guidance literature:: With acetic acid; In N,N-dimethyl-formamide; 1.) 20 deg C, 48 h, 2.) 40 deg C, 24 h;
DOI:10.1021/jm00133a008

Reference yield:

: 7473-16-7
ethyl 4-carboxy-1,3,5-trimethylpyrrole-2-carboxylate

: 75792-57-3
N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / NaH / 90 °C / 10 Torr

2: 75 percent / diphenylphosphoryl azide (DPPA), Et₃N / acetonitrile / 1.5 h / 50 °C

3: 95 percent / CuCl / 5 h / 60 °C

4: H₂ / 10percent Pd/C / dioxane / 12 h

5: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

6: 70 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight

7: 100 percent / H₂ / 10percent Pd/C / dioxane; ethanol / 4 h / Heating

8: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

9: 85 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 48 h, 2.) 40 deg C, 24 h

With diphenylphosphoranyl azide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium hydride; acetic acid; triethylamine; copper(l) chloride; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00133a008

Reference yield:

: 75792-41-5
ethyl 4-isocyanato-1,3,5-trimethylpyrrole-2-carboxylate

: 75792-57-3
N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: Et₃N / acetonitrile / 5 h / 50 °C

2: H₂ / 10percent Pd/C / methanol

3: 100 percent / Na / 4 h / 100 °C

5: H₂ / 10percent Pd/C / dioxane / 12 h

6: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

7: 70 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight

8: 100 percent / H₂ / 10percent Pd/C / dioxane; ethanol / 4 h / Heating

9: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

10: 85 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 48 h, 2.) 40 deg C, 24 h

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00133a008