1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Base Information

Chemical Name:1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone
CAS No.:544455-49-4
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

Synonyms:1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Suppliers and Price of 1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

There total 11 articles about 1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 544455-44-9
1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

: 544455-49-4
1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 0.5h;
DOI:10.1016/S0040-4039(03)00218-1

Reference yield:

: 150-76-5
4-methoxy-phenol

: 544455-49-4
1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 11 steps

1: 70 percent / K₂OsO₄*2H₂O; (DHQD)2PHAL; LiOH / 2-methyl-propan-2-ol; H₂O / 8 h / 4 °C

2: 80 percent / NaH / dimethylformamide / 8 h / 0 °C

3: 100 percent / LiBH₄ / diethyl ether / 0.25 h

4: 100 percent / TEA; DMAP / CH₂Cl₂ / 4 h / 25 °C

5: 95 percent / KH; 18-crown-ether / tetrahydrofuran / 5 h / 25 °C

6: 100 percent / tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C

7: 90 percent / periodinane / CH₂Cl₂ / 1 h / 25 °C

8: 94 percent / LiBr; DBU / tetrahydrofuran / 2 h / 25 °C

9: 80 percent / Grubb's bis(tricyclohexylphosphinebenzylidene Ru(IV)Cl₂ / toluene / 2 h / 90 °C

10: 85 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 25 °C

With dmap; lithium hydroxide; potassium osmate(VI); lithium borohydride; 18-crown-ether; TEA; tetrabutyl ammonium fluoride; potassium hydride; sodium hydride; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-bis(9-O-dihydroquinidine)phthalazine; trifluoroacetic acid; lithium bromide; Grubbs catalyst first generation; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 2: Sharpless asymmetric aminohydroxylation / 8: Dess-Martin oxidation / 9: Horner-Wadsworth-Emmons olefination / 10: ring closing metathesis;
DOI:10.1016/S0040-4039(03)00218-1

Reference yield:

: 544455-38-1
ethyl (2E)-4-(4-methoxyphenoxy)but-2-enoate

: 544455-49-4
1-[(2R,3R)-3-Hydroxy-2-(4-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 10 steps

1: 70 percent / K₂OsO₄*2H₂O; (DHQD)2PHAL; LiOH / 2-methyl-propan-2-ol; H₂O / 8 h / 4 °C

2: 80 percent / NaH / dimethylformamide / 8 h / 0 °C

3: 100 percent / LiBH₄ / diethyl ether / 0.25 h

4: 100 percent / TEA; DMAP / CH₂Cl₂ / 4 h / 25 °C

5: 95 percent / KH; 18-crown-ether / tetrahydrofuran / 5 h / 25 °C

6: 100 percent / tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C

7: 90 percent / periodinane / CH₂Cl₂ / 1 h / 25 °C

8: 94 percent / LiBr; DBU / tetrahydrofuran / 2 h / 25 °C

9: 80 percent / Grubb's bis(tricyclohexylphosphinebenzylidene Ru(IV)Cl₂ / toluene / 2 h / 90 °C

10: 85 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 25 °C

With dmap; lithium hydroxide; potassium osmate(VI); lithium borohydride; 18-crown-ether; TEA; tetrabutyl ammonium fluoride; potassium hydride; sodium hydride; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-bis(9-O-dihydroquinidine)phthalazine; trifluoroacetic acid; lithium bromide; Grubbs catalyst first generation; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 1: Sharpless asymmetric aminohydroxylation / 7: Dess-Martin oxidation / 8: Horner-Wadsworth-Emmons olefination / 9: ring closing metathesis;
DOI:10.1016/S0040-4039(03)00218-1