Technology Process of 8-(toluene-4-sulfonyl)-1,4-dioxa-8,11-diaza-cyclotetradecane
There total 4 articles about 8-(toluene-4-sulfonyl)-1,4-dioxa-8,11-diaza-cyclotetradecane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1021/jm990211i
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaOH / H2O; diethyl ether / 20 °C
2: Cs2CO3 / dimethylformamide / 65 °C
3: 3 percent sodium amalgam, Na2HPO4 / tetrahydrofuran; methanol / 44 h / Heating
4: Et3N / CH2Cl2 / 2 h / 20 °C
With
sodium hydroxide; disodium hydrogenphosphate; sodium amalgam; caesium carbonate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
1: Tosylation / 2: Cyclization / 3: detosylation / 4: Tosylation;
DOI:10.1021/jm990211i
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Cs2CO3 / dimethylformamide / 65 °C
2: 3 percent sodium amalgam, Na2HPO4 / tetrahydrofuran; methanol / 44 h / Heating
3: Et3N / CH2Cl2 / 2 h / 20 °C
With
disodium hydrogenphosphate; sodium amalgam; caesium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1: Cyclization / 2: detosylation / 3: Tosylation;
DOI:10.1021/jm990211i
