benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate

Base Information

Chemical Name:benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate
CAS No.:129441-54-9
Molecular Formula:C₂₃H₃₂N₂O₆Si
Molecular Weight:460.602
Hs Code.:

Synonyms:benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate

Suppliers and Price of benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate

There total 12 articles about benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 129441-53-8
benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carboxyl-1-oxa-3-cephem-4-carboxylate

: 129441-54-9
benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate

Guidance literature:: With ammonium hydroxide; O-phenyl phosphorodichloridate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; at -25 ℃; for 0.5h;

Reference yield:

: 76899-07-5,78963-47-0,78963-48-1,78963-60-7,80951-41-3,81275-02-7,85647-75-2,85954-95-6,92217-74-8,104527-11-9,76855-69-1
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one

: 129441-54-9
benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1: 86 percent / zinc acetate / benzene / 8.5 h / Heating

2: 49 percent / 1.) oxalyl chloride, DMSO, 2.) Et₃N / CH₂Cl₂ / -50 °C / 1.) 15 min, 2.) 1 h

3: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

4: 2,6-lutidine, thionyl chloride / CH₂Cl₂ / 0.75 h / -40 °C

5: CH₂Cl₂ / Ambient temperature

6: 60 percent / 5.18 M NaOMe / methanol / 2.5 h / -40 °C

7: 87 percent / toluene / 3.5 h / 100 °C

8: 99 percent / 1.) oxalyl chloride, DMSO, 2.) Et₃N / CH₂Cl₂ / -40 °C / 1.) 20 min, 2.) 1 h

9: sodium chlorite, sodium dihydrogen phosphate / tetrahydrofuran; various solvent(s); H₂O / 3.5 h / Ambient temperature

10: 40 percent / phenyl dichlorophosphate, Et₃N, 1.6 M ammonia/DMF / CH₂Cl₂ / 0.5 h / -25 °C

With 2,6-dimethylpyridine; ammonium hydroxide; sodium chlorite; thionyl chloride; sodium dihydrogen phosphate; oxalyl dichloride; zinc diacetate; sodium methylate; dimethyl sulfoxide; O-phenyl phosphorodichloridate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; benzene;

Reference yield:

: 123657-02-3
(3R,4R)-4-allyloxy-3-<(1R)-1-tert-butyldimethylsilyloxyethyl>azetidin-2-one

: 129441-54-9
benzyl 7α-<(1R)-1-tert-butyldimethylsilyloxyethyl>-3-carbamoyl-1-oxa-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1: 91 percent / 70percent m-chloroperbenzoic acid, NaHCO₃ / CH₂Cl₂ / Ambient temperature

2: 77 percent / Ti(iOPr)4 / 6 h / Ambient temperature

3: 49 percent / 1.) oxalyl chloride, DMSO, 2.) Et₃N / CH₂Cl₂ / -50 °C / 1.) 15 min, 2.) 1 h

4: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

5: 2,6-lutidine, thionyl chloride / CH₂Cl₂ / 0.75 h / -40 °C

6: CH₂Cl₂ / Ambient temperature

7: 60 percent / 5.18 M NaOMe / methanol / 2.5 h / -40 °C

8: 87 percent / toluene / 3.5 h / 100 °C

9: 99 percent / 1.) oxalyl chloride, DMSO, 2.) Et₃N / CH₂Cl₂ / -40 °C / 1.) 20 min, 2.) 1 h

10: sodium chlorite, sodium dihydrogen phosphate / tetrahydrofuran; various solvent(s); H₂O / 3.5 h / Ambient temperature

11: 40 percent / phenyl dichlorophosphate, Et₃N, 1.6 M ammonia/DMF / CH₂Cl₂ / 0.5 h / -25 °C

With 2,6-dimethylpyridine; titanium(IV) isopropylate; ammonium hydroxide; sodium chlorite; thionyl chloride; sodium dihydrogen phosphate; oxalyl dichloride; sodium methylate; sodium hydrogencarbonate; dimethyl sulfoxide; O-phenyl phosphorodichloridate; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene;