Technology Process of 2-cyano-1-(8-(cyclohexyl(3-morpholinopropyl)amino)octyl)-3-(pyridin-4-yl)guanidine
There total 8 articles about 2-cyano-1-(8-(cyclohexyl(3-morpholinopropyl)amino)octyl)-3-(pyridin-4-yl)guanidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
DMAP polystyrene supported;
In
pyridine;
at 80 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C / Microwaves
3: hydrazine hydrate / 0.33 h / 130 °C / Microwaves
4: triethylamine / DMAP polystyrene supported / pyridine / 80 °C
With
hydrazine hydrate; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine;
DMAP polystyrene supported;
In
pyridine; 1,1-dichloroethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N,N-dimethyl-formamide / 158 °C
2: carbon tetrabromide; triphenylphosphine / acetonitrile / 2.5 h / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C / Microwaves
4: hydrazine hydrate / 0.33 h / 130 °C / Microwaves
5: triethylamine / DMAP polystyrene supported / pyridine / 80 °C
With
hydrazine hydrate; carbon tetrabromide; potassium carbonate; triethylamine; triphenylphosphine;
DMAP polystyrene supported;
In
pyridine; N,N-dimethyl-formamide; acetonitrile;