4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one

Base Information

Chemical Name:4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one
CAS No.:1352287-94-5
Molecular Formula:C₂₆H₂₅NO₃
Molecular Weight:399.489
Hs Code.:

Synonyms:4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one

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Chemical Property of 4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one

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Technology Process of 4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one

There total 7 articles about 4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 93-51-6
2-Methoxy-4-methylphenol

: 1352287-38-7
4-hydroxymethyl-2-methyl-3-o-tolyl-2H-isoquinolin-1-one

: 1352287-94-5
4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.10.053

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 1352287-94-5
4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 0 °C / Reflux; Inert atmosphere

2.1: dichloromethane / 0 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 10 h / -78 - -50 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: Reflux; Inert atmosphere

5.1: trichlorophosphate / 2 h / Cooling with ice; Inert atmosphere

5.2: 19 h / 60 °C / Inert atmosphere

5.3: Cooling with ice; Inert atmosphere

6.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

6.2: Inert atmosphere

7.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; methanol; hexane; dichloromethane; 5.2: Vilsmeier-Haack reaction / 7.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.10.053

Reference yield:

: 1352287-24-1
2-methyl-1-oxo-3-o-tolyl-1,2-dihydro-isoquinoline-4-carbaldehyde

: 1352287-94-5
4-(2-methoxy-4-methyl-phenoxymethyl)-2-methyl-3-o-tolyl-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; 2.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.10.053