1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate

Base Information

Chemical Name:1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate
CAS No.:143366-69-2
Molecular Formula:C₃₀H₃₄NO₁₈P₃
Molecular Weight:789.517
Hs Code.:

Synonyms:1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate

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Chemical Property of 1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate

Chemical Property:

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Technology Process of 1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate

There total 8 articles about 1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143366-68-1,143396-75-2
1-O-<(Benzyloxy)-3-(benzyloxycarbonylamino)propoxyphosphinyl>-2,3,6-tri-O-benzoyl-4,5-bis-O-(dibenzyloxyphosphinyl)-D-myo-inositol

: 143366-69-2
1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate

Guidance literature:: With hydrogen; palladium hydroxide - carbon; In acetic acid; for 6h; under 760 Torr; Yield given;
DOI:10.1016/S0008-6215(00)90513-5

Reference yield:

: 34637-22-4
3-[(N-benzyloxycarbonyl)amino]propanol

: 143366-69-2
1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate

Guidance literature:: Multi-step reaction with 5 steps

1: 1) diisopropylethylamine, 2) benzyl alcohol / 1) THF, 25 deg C, 18 h, 2) THF, 25 deg C, 4 h

2: 1) 1H-tetrazole, 2) m-chloroperoxybenzoic acid / 1) CH₂Cl₂, 25 deg C, 8 h, 2) -78 deg C to 25 deg C, overnight

3: 88percent HCOOH, H₂O / tetrahydrofuran / 0.5 h / 25 °C

4: 1) 1H-tetrazole, 2) m-chloroperoxybenzoic acid / 1) CH₂Cl₂, 25 deg C, 1 h, 2) -78 deg C to 25 deg C, overnight

5: H₂ / Pd(OH)2-C / acetic acid / 6 h / 760 Torr

With 1H-tetrazole; formic acid; water; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; benzyl alcohol; palladium hydroxide - carbon; In tetrahydrofuran; acetic acid;
DOI:10.1016/S0008-6215(00)90513-5

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 143366-69-2
1-<3-Aminopropoxy(hydroxy)phosphinyl>-2,3,6-tri-O-benzoyl-D-myo-inositol 4,5-bisphosphate

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / 2 M NaOH / toluene / 48 h / 25 °C

2: 1) diisopropylethylamine, 2) benzyl alcohol / 1) THF, 25 deg C, 18 h, 2) THF, 25 deg C, 4 h

3: 1) 1H-tetrazole, 2) m-chloroperoxybenzoic acid / 1) CH₂Cl₂, 25 deg C, 8 h, 2) -78 deg C to 25 deg C, overnight

4: 88percent HCOOH, H₂O / tetrahydrofuran / 0.5 h / 25 °C

5: 1) 1H-tetrazole, 2) m-chloroperoxybenzoic acid / 1) CH₂Cl₂, 25 deg C, 1 h, 2) -78 deg C to 25 deg C, overnight

6: H₂ / Pd(OH)2-C / acetic acid / 6 h / 760 Torr

With 1H-tetrazole; sodium hydroxide; formic acid; water; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; benzyl alcohol; palladium hydroxide - carbon; In tetrahydrofuran; acetic acid; toluene;
DOI:10.1016/S0008-6215(00)90513-5