N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide
• CAS No.: 1055972-09-2
• Molecular Formula: C₁₅H₁₃F₃N₆O₂
• Molecular Weight: 366.302

Synonyms:N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide

Chemical Property of N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide

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Technology Process of N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide

There total 5 articles about N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,2,2-trifluoro-N-(3-(hydroxymethyl)benzyl)-acetamide (948903-64-8) + 6-(1-methylpyrrolidin-1-ium-1-yl)-7H-purin-2-amine chloride (680622-68-8) → N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide (1055972-09-2)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 25 ℃; for 3h; Inert atmosphere;

Reference yield: 51.0%

2,2,2-trifluoro-N-(3-(hydroxymethyl)benzyl)-acetamide (948903-64-8) + 1‐(2‐amino‐9H‐purin‐6‐yl)‐1‐methylpyrrolidin‐1‐ium chloride → N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide (1055972-09-2)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; for 4h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.03.041

Reference yield:

2,2,2-trifluoro-N-(3-(hydroxymethyl)benzyl)-acetamide (948903-64-8) + 1-(2-amino-9H-purin-6-yl)-1-methyl-pyrrolidinium → N-(3-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-2,2,2-trifluoroacetamide (1055972-09-2)

Guidance literature:

With potassium tert-butylate; at 25 ℃; for 2.5h; Inert atmosphere;

upstream raw materials:

2,2,2-trifluoro-N-(3-(hydroxymethyl)benzyl)-acetamide

2-Amino-6-chloropurin

6-(1-methylpyrrolidin-1-ium-1-yl)-7H-purin-2-amine chloride

2-amino-6-chloropurine

Downstream raw materials:

O⁶-[3-(Aminomethyl)benzyl]guanine

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