[(S)-8-tert-Butoxycarbonylamino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(S)-8-tert-Butoxycarbonylamino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester
CAS No.:119860-19-4
Molecular Formula:C₂₉H₃₈F₂N₄O₉
Molecular Weight:624.639
Hs Code.:

Synonyms:[(S)-8-tert-Butoxycarbonylamino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester

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Chemical Property of [(S)-8-tert-Butoxycarbonylamino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester

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Technology Process of [(S)-8-tert-Butoxycarbonylamino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester

There total 10 articles about [(S)-8-tert-Butoxycarbonylamino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 119860-20-7
[(S)-8-Amino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester

: 119860-19-4
[(S)-8-tert-Butoxycarbonylamino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)82154-1

Reference yield: 32.0%

: 119860-19-4
N⁸-benzyloxycarbonyl-N¹-tert-butoxycarbonyl-2,2-difluoro-3-hydroxy-N⁴-(4-nitrobenzyloxycarbonyl)-1,4,8-octanetriamine

Guidance literature:

Reference yield:

: 138802-24-1
(R,S)-1-formyl-1-(4-nitrobenzyl)-5-benzylpentylene dicarbamate

: 119860-19-4
N⁸-benzyloxycarbonyl-N¹-tert-butoxycarbonyl-2,2-difluoro-3-hydroxy-N⁴-(4-nitrobenzyloxycarbonyl)-1,4,8-octanetriamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) zinc, iodine / 1.) THF, rt, 15 min, ultrasonication; 2.) THF, rt, 35 min, ultrasonication

2: 89 percent / ammonia gas / diethyl ether / -78 °C

3: 1.) BH₃(CH₃)2S; 2.) sat.hydrogen chloride; 3.) NaHCO₃, Na₂CO₃, / 1.) THF, reflux, 4 h; 2.) Et₂O, 0.45 min; 3.) water/THF, rt, 15 h

With hydrogenchloride; dimethylsulfide borane complex; ammonia; iodine; sodium hydrogencarbonate; sodium carbonate; zinc; In diethyl ether;
DOI:10.1016/0040-4020(95)00896-G