6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione
• CAS No.: 1006300-03-3
• Molecular Formula: C₁₅H₁₅BrN₂O₃
• Molecular Weight: 351.2
• Mol file: 1006300-03-3.mol

Synonyms:6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione

Chemical Property of 6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione

There total 2 articles about 6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3-bromo-5-methyl-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone (1006300-02-2) → 6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione (1006300-03-3)

Guidance literature:

With hydrogenchloride; water; for 3h; Heating / reflux;

Reference yield: 62.0%

5-isopropyl-6-chloro-2,4-dimethoxypyrimidine (96606-04-1) + 2-(3-bromo-5-methylphenyl)acetonitrile (871116-91-5) → 6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione (1006300-03-3)

Guidance literature:

5-isopropyl-6-chloro-2,4-dimethoxypyrimidine; 2-(3-bromo-5-methylphenyl)acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 7h;

With oxygen; sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

With water; hydrogen bromide; In N,N-dimethyl-formamide; for 18h; Product distribution / selectivity; Heating / reflux;

Reference yield: 96.0%

6-(3-bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione (1006300-03-3) + dicyanozinc (557-21-1) → 3-(5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl)-5-methyl-benzonitrile (1006300-12-4)

Guidance literature:

With zinc diacetate; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl acetamide; at 120 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

(3-bromo-5-methyl-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone

5-isopropyl-6-chloro-2,4-dimethoxypyrimidine

2-(3-bromo-5-methylphenyl)acetonitrile

Downstream raw materials:

N-{4-[6-(3-Bromo-5-methyl-benzoyl)-5-isopropyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-pyridin-2-yl}-acetamide

6-(3-bromo-5-methyl-benzoyl)-1-[2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-1H-pyrimidine-2,4-dione

6-(3-bromo-5-methyl-benzoyl)-1-[2-chloro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-1H-pyrimidine-2,4-dione

3-[[3-ethyl-1,2,3,6-tetrahydro-5-(1-methylethyl)-2,6-dioxo-4-pyrimidinyl]carbonyl]-5-methylbenzonitrile