6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde

Base Information

Chemical Name:6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde
CAS No.:325705-78-0
Molecular Formula:C₂₇H₂₈N₄O₆
Molecular Weight:504.543
Hs Code.:

Synonyms:6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde

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Chemical Property of 6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde

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Technology Process of 6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde

There total 4 articles about 6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 325705-77-9
6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine

: 325705-78-0
6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 23 ℃; for 1h;
DOI:10.1016/S0040-4020(00)00970-4

Reference yield:

: 102147-76-2
5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylideneuridine

: 325705-78-0
6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / -78 °C

1.2: -78 °C

2.1: 73 percent / glacial AcOH / CH₂Cl₂; diethyl ether / 72 h / 23 °C

3.1: 94 percent / TBAF / tetrahydrofuran / 36 h / 23 °C

4.1: 94 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 23 °C

With tetrabutyl ammonium fluoride; Dess-Martin periodane; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Metallation / 1.2: Formylation / 2.1: Cyclization / 3.1: desilylation / 4.1: Oxidation;
DOI:10.1016/S0040-4020(00)00970-4

Reference yield:

: 177779-23-6
6-formyl-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneuridine

: 325705-78-0
6-(1,3-diphenylimidazolidin-2-yl)-2',3'-O-isopropylideneuridine 5'-carboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / glacial AcOH / CH₂Cl₂; diethyl ether / 72 h / 23 °C

2: 94 percent / TBAF / tetrahydrofuran / 36 h / 23 °C

3: 94 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 23 °C

With tetrabutyl ammonium fluoride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Cyclization / 2: desilylation / 3: Oxidation;
DOI:10.1016/S0040-4020(00)00970-4