5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline

Base Information

• Chemical Name: 5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline
• CAS No.: 268745-31-9
• Molecular Formula: C₂₀H₁₁F₆NO₂S
• Molecular Weight: 443.369

Synonyms:5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline

Chemical Property of 5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline

Chemical Property:

Purity/Quality:

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Technology Process of 5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline

There total 2 articles about 5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-[8-Benzylsulfanyl-5-(2,2,2-trifluoro-acetyl)-quinolin-7-yl]-2,2,2-trifluoro-ethanone (268745-25-1) → 5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline (268745-31-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; for 4h; Heating;

DOI:10.1055/s-2000-6243

Reference yield:

N,N-dimethylquinoline-8-amine (29526-42-9) → 5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline (268745-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / pyridine / CHCl₃ / 24 h / 50 °C

2: 100 percent / acetonitrile / 8 h / Heating

3: 89 percent / 1,4-diazabicyclo[2.2.2]octane / acetonitrile / 4 h / Heating

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In chloroform; acetonitrile; 1: Acylation / 2: Substitution / 3: Cyclization;

DOI:10.1055/s-2000-6243

Reference yield: 100.0%

5-Trifluoroacetyl-3-trifluoromethyl-3-hydroxy-2-phenyl-2,3-dihydrothieno[3,2-h]quinoline (268745-31-9) → 2,2,2-trifluoro-1-(2-phenyl-3-trifluoromethyl-thieno[3,2-h]quinolin-5-yl)-ethanone

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/s-2000-6243

upstream raw materials:

1-[8-Benzylsulfanyl-5-(2,2,2-trifluoro-acetyl)-quinolin-7-yl]-2,2,2-trifluoro-ethanone

N,N-dimethylquinoline-8-amine

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