N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

Base Information

• Chemical Name: N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
• CAS No.: 108718-20-3
• Molecular Formula: C₁₅H₁₂N₄O₄S
• Molecular Weight: 344.351
• Mol file: 108718-20-3.mol

Synonyms:N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

Chemical Property of N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

There total 6 articles about N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.9%

N'-[(Z)-(2-nitrophenyl)methylidene]pyridine-4-carbohydrazide (1262213-17-1,180613-20-1) + mercaptoacetic acid (68-11-1) → N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide (108718-20-3)

Guidance literature:

With zinc(II) chloride; In tetrahydrofuran; Molecular sieve; Sonication;

DOI:10.5012/jkcs.2011.55.6.960

Reference yield: 65.0%

isoniazid (54-85-3,7640-37-1) + mercaptoacetic acid (68-11-1) + 2-nitro-benzaldehyde (552-89-6) → N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide (108718-20-3)

Guidance literature:

at 80 ℃; for 7h;

DOI:10.1080/10426507.2011.608099

Reference yield:

isoniazid (54-85-3,7640-37-1) → N-[2-(2-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide (108718-20-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol / Reflux

2: 12 h / 120 - 125 °C

With acetic acid; In methanol;

DOI:10.2298/JSC101104092G

upstream raw materials:

isoniazid

(E)-N'-(2-nitrobenzylidene)isonicotinohydrazide

mercaptoacetic acid

2-nitro-benzaldehyde