2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide

Base Information

• Chemical Name: 2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide
• CAS No.: 1350538-36-1
• Molecular Formula: C₂₀H₂₃N₅O₉S₂
• Molecular Weight: 541.563

Synonyms:2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide

Chemical Property of 2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide

Chemical Property:

Purity/Quality:

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Technology Process of 2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide

There total 5 articles about 2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-(2-aminocyclohexyl)-2-nitrobenzene-1-sulfonamide (1350538-33-8) + 2-[(2-nitrobenzene)sulfonamido]acetic acid (15054-42-9) → 2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide (1350538-36-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 8h;

DOI:10.3987/COM-11-12249

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → 2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide (1350538-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 3.5 h / 0 - 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 8 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

DOI:10.3987/COM-11-12249

Reference yield:

trans-1,2-(R,R)-diammoniumcyclohexane tartrate (32044-22-7,39961-95-0) → 2-(2-nitrophenylsulfonylamino)-N-[(1R,2R)-2-(2-nitrophenylsulfonylamino)cyclohexyl]acetamide (1350538-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; sodium hydroxide / dichloromethane / 0.17 h / 0 °C

2: dichloromethane / 3.5 h / 0 - 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 8 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.3987/COM-11-12249

upstream raw materials:

N-(2-aminocyclohexyl)-2-nitrobenzene-1-sulfonamide

2-[(2-nitrobenzene)sulfonamido]acetic acid

trans-1,2-(R,R)-diammoniumcyclohexane tartrate

(1R,2R)-1,2-diaminocyclohexane

Downstream raw materials:

(4R,9R)-3,13-bis(2-nitrobenzenesulfonyl)-3,10,13,19-tetraazatricyclo[13.3.1.0(4,9)]nonadeca-1⁽¹⁹⁾,15,17-trien-11-one

(4R,9R)-3,13-bis(2-nitrobenzenesulfonyl)-19-oxy-3,10,13,19-tetraazatricyclo[13.3.1.0(4,9)]nonadeca-1⁽¹⁹⁾,15,17-trien-11-one

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