2-Amino-3-bromo-5-fluoropyridine

Base Information

• Chemical Name: 2-Amino-3-bromo-5-fluoropyridine
• CAS No.: 869557-43-7
• Molecular Formula: C5H4BrFN2
• Molecular Weight: 191.003
• Hs Code.: 29333990
• European Community (EC) Number: 675-556-6
• DSSTox Substance ID: DTXSID80583124
• Nikkaji Number: J3.484.454B
• Wikidata: Q72438574
• Mol file: 869557-43-7.mol

Synonyms:2-Amino-3-bromo-5-fluoropyridine;869557-43-7;3-bromo-5-fluoropyridin-2-amine;3-bromo-5-fluoro-pyridin-2-ylamine;MFCD03092924;2-amino-5-fluoro-3-bromopyridine;EN300-99165;2-PYRIDINAMINE, 3-BROMO-5-FLUORO-;3-BROMO-5-FLUORO-2-PYRIDINAMINE;SCHEMBL473753;2-Amino-3--5-Fluoro Pyridine;DTXSID80583124;KXSQMCRVUAALNE-UHFFFAOYSA-N;BDBM626235;3-bromo-5-fluoro-pyridine-2-ylamine;AKOS005137899;AC-9415;CS-W010739;HY-W010023;PS-8361;2-Amino-3-bromo-5-fluoropyridine, 97%;SY064360;AM20070154;J-512019;J-517024;Z1201621986;2-Amino-5-fluoro-3-bromopyridine;3-bromo-5-fluoro-2-Aminopyridine;3-Bromo-2-amino-5-fluoropyridine;5-Fluoro-2-amino-3-bromopyridine;5-Fluoro-3-bromo-2-aminopyridine

Chemical Property of 2-Amino-3-bromo-5-fluoropyridine

Chemical Property:

• Melting Point: 61-63 °C
• Boiling Point: 220 °C at 760 mmHg
• PKA: 1.86±0.49(Predicted)
• Flash Point: 86.8 °C
• PSA: 38.91000
• Density: 1.813 g/cm³
• LogP: 2.14660
• Storage Temp.: Keep Cold
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 189.95419
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-bromo-5-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Br)N)F
• Uses: 2-Amino-3-bromo-5-fluoropyridine is a reactant used in the synthesis of cyano heteroaryl bromides.

Technology Process of 2-Amino-3-bromo-5-fluoropyridine

There total 2 articles about 2-Amino-3-bromo-5-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-amino-5-fluoropyridine (21717-96-4) → 3-bromo-5-fluoropyridin-2-amine (869557-43-7)

Guidance literature:

With sulfuric acid; bromine; In water; at 30 - 50 ℃; for 26h; Reagent/catalyst; Large scale;

Reference yield:

→ 3-bromo-5-fluoropyridin-2-amine (869557-43-7)

Guidance literature:

Reference yield: 69.0%

3-bromo-5-fluoropyridin-2-amine (869557-43-7) + phenylacetylene (536-74-3) → 5-fluoro-3-(2-phenylethynyl)pyridin-2-amine

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In acetonitrile; at 75 ℃; for 5h; Inert atmosphere;

upstream raw materials:

2-amino-5-fluoropyridine

Downstream raw materials:

2-amino-5-fluoronicotinonitrile

2,3-dibromo-5-fluoro-pyridine

3-bromo-5-fluoro-2-nitropyridine

3-bromo-2,5-difluoro-pyridine