(3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacosane-2,5,11,14,18,21,24-heptaone

Base Information

• Chemical Name: (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacosane-2,5,11,14,18,21,24-heptaone
• CAS No.: 143381-36-6
• Molecular Formula: C₃₉H₅₁N₇O₈
• Molecular Weight: 745.876
• Mol file: 143381-36-6.mol

Synonyms:(3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacosane-2,5,11,14,18,21,24-heptaone

Chemical Property of (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacosane-2,5,11,14,18,21,24-heptaone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacosane-2,5,11,14,18,21,24-heptaone

There total 14 articles about (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacosane-2,5,11,14,18,21,24-heptaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-des-(3-hydroxy-picolinoyl)-1-<2-(3-hydroxypyridyl)>-methyl-pristinamycin IA → (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.06,10]hexacosane-2,5,11,14,18,21,24-heptaone (143381-36-6)

Guidance literature:

In ethanol; sulfuric acid; at 25 ℃; controlled potential electrochem. reduction, (-)Hg/Pt(+), -1000 mV vs. s.c.e.;

DOI:10.1016/S0040-4020(01)80650-5

Reference yield: 80.0%

Pyridine-2-carboxylic acid [(3S,6S,12R,15S,16R,19S,22S)-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.06,10]hexacos-15-yl]-amide → (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.06,10]hexacosane-2,5,11,14,18,21,24-heptaone (143381-36-6)

Guidance literature:

In sulfuric acid; at 25 ℃; controlled potential electrochem. reduction, (-)Hg/Pt(+), -1000 mV vs. s.c.e.;

DOI:10.1016/S0040-4020(01)80650-5

Reference yield: 80.0%

N-[(3S,6S,12R,15S,16R,19S,22S)-3-(4-Dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.06,10]hexacos-15-yl]-isonicotinamide → (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.06,10]hexacosane-2,5,11,14,18,21,24-heptaone (143381-36-6)

Guidance literature:

In sulfuric acid; at 25 ℃; controlled potential electrochem. reduction, (-)Hg/Pt(+), -1000 mV vs. s.c.e.;

DOI:10.1016/S0040-4020(01)80650-5

upstream raw materials:

3-Methoxy-pyridine-2-carboxylic acid [(3S,6S,12R,15S,16R,19S,22S)-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacos-15-yl]-amide

pristinamycin IA

Downstream raw materials:

3-Methoxy-pyridine-2-carboxylic acid [(3S,6S,12R,15S,16R,19S,22S)-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacos-15-yl]-amide

C₄₆H₅₉N₉O₁₀